Using CRISPR-Cas9, researchers at Columbia University Medical Center have converted a natural bacterial immune system into a microscopic data recorder, laying the groundwork for a new class of technologies that use bacterial cells for everything from disease diagnosis to environmental monitoring.
CRISPR technology is a simple yet powerful tool for editing genomes. It allows researchers to easily alter DNA sequences and modify gene function. Its many potential applications include correcting genetic defects, treating and preventing the spread of diseases and improving crops. However, its promise also raises ethical concerns.
In popular usage, "CRISPR" (pronounced "crisper") is shorthand for "CRISPR-Cas9." CRISPRs are specialized stretches of DNA. The protein Cas9 (or "CRISPR-associated") is an enzyme that acts like a pair of molecular scissors, capable of cutting strands of DNA.
A team from the Center for Genome Engineering, within the Institute for Basic Research (IBS), succeeded in editing two genes that contribute to the fat contents of soybean oil using the new CRISPR-Cpf1 technology: an alternative of the more widely used gene editing tool CRISPR-Cas9.
The US patent office ruled on Wednesday that hotly disputed patents on the revolutionary genome-editing technology CRISPR-Cas9 belong to the Broad Institute of Harvard and MIT, dealing a blow to the University of California in its efforts to overturn those patents.
Clinical trials for genome editing of the human germline – adding, removing, or replacing DNA base pairs in gametes or early embryos – could be permitted in the future, but only for serious conditions under stringent oversight, says a new report from the National Academy of Sciences and the National Academy of Medicine. The report outlines several criteria that should be met before allowing germline editing clinical trials to go forward.
Home gardeners in the U.S. and Europe can thank early tomato growers, who selected plants that ignore seasonal changes in day length, for enabling their backyard bounty. Researchers in the lab of Associate Professor Zachary Lippman at CSHL, compared the genomes of early- and late-flowering wild tomato to unpack the tomato genome.
You’ve probably seen and heard a lot about genetically modified food in recent months: on the news, among friends, even as a label on the food you eat. But for all the information and opinions out there, there’s still very little explanation about what exactly genetically modified organisms are. To get a good answer, it’s helpful to talk with someone who actually makes them.
Matthew Willmann is director of the College of Agriculture and Life Sciences Plant Transformation Facility at Cornell University. He is someone who makes genetically engineered plants. Not for food and not for commercial purposes—Willmann currently uses biotechnology to modify crops for research only.
For something that’s been called “a household name for molecular biologists,” many of you have probably never heard of CRISPR, and don’t know why you should be excited (or, possibly, terrified). It’s all about advanced gene therapy and splicing – and it’s bringing sci-fi ideas straight into reality. Here’s a quick FAQ on the science behind CRISPR and why the world is paying such close attention.
How can one technology potentially do so many, and such world-altering, things? This video explain what CRISPR actually is, how exactly it works, and why so many scientists believe it's such a promising tool.